Oliver T Fackler Selected Research

nef Gene Products (nef Gene Product)

12/2015	Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor.
4/2012	Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.
1/2012	HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling.
3/2011	Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.
12/2008	Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
4/2005	The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.
4/2004	Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.
4/2002	Live and let die: Nef functions beyond HIV replication.

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Oliver T Fackler Research Topics

Disease

20	Infections 12/2021 - 04/2002
7	Disease Progression 01/2022 - 12/2008
7	HIV Infections (HIV Infection) 12/2020 - 02/2005
6	Acquired Immunodeficiency Syndrome (AIDS) 11/2018 - 04/2004
4	Blister (Bulla) 04/2012 - 11/2007
2	Neoplasms (Cancer) 01/2018 - 08/2015
2	Virus Diseases (Viral Diseases) 10/2017 - 08/2006
2	3 Autosomal Dominant Hypercholesterolemia 09/2008 - 02/2006
2	Superinfection 11/2006 - 04/2005
1	COVID-19 01/2022
1	Autoimmune Diseases (Autoimmune Disease) 01/2020
1	Measles 01/2019
1	Flavivirus Infections 10/2017
1	Zika Virus Infection 10/2017
1	Bites and Stings (Sting) 01/2016
1	Neoplasm Metastasis (Metastasis) 08/2015
1	Hepatitis A (Hepatitis, Infectious) 11/2014
1	Malaria 01/2011

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2005
8	nef Gene Products (nef Gene Product)IBA 12/2015 - 04/2002
6	Antiviral Agents (Antivirals)IBA 01/2022 - 03/2009
3	CytokinesIBA 12/2021 - 01/2009
3	LigandsIBA 01/2020 - 05/2016
3	Viral ProteinsIBA 11/2018 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2022 - 01/2011
2	ForminsIBA 04/2012 - 09/2008
2	GTP Phosphohydrolases (GTPases)IBA 04/2012 - 09/2008
2	Biological ProductsIBA 11/2011 - 08/2006
1	remdesivirIBA 01/2022
1	CobicistatIBA 01/2022
1	vesicular stomatitis virus G proteinIBA 12/2021
1	Neutralizing AntibodiesIBA 12/2020
1	AntigensIBA 12/2020
1	Immunoglobulin G (IgG)IBA 12/2020
1	CollagenIBA 01/2020
1	Antiviral Restriction FactorsIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	InterferonsIBA 01/2020
1	InterleukinsIBA 01/2020
1	Gold CompoundsIBA 01/2020
1	Glycoproteins (Glycoprotein)IBA 01/2019
1	baysilon (polydimethylsiloxane)IBA 01/2018
1	PlasticsIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 10/2017
1	Peptide Initiation Factors (Initiation Factor)IBA 10/2017
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 10/2017
1	Eukaryotic Initiation Factor-4EIBA 10/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	IntegrinsIBA 08/2015
1	triphosphoric acid (triphosphate)IBA 07/2015
1	Phosphodiesterase I (5' Exonuclease)IBA 07/2015
1	guanylyl-(3'-5')-guanosineIBA 01/2015
1	VLDL LipoproteinsIBA 11/2014
1	ApolipoproteinsIBA 11/2014
1	Viral Envelope ProteinsIBA 11/2014
1	Nonsense Codon (Nonsense Mutation)IBA 11/2012
1	Protein Isoforms (Isoforms)IBA 04/2012
1	LipidsIBA 03/2012
1	Bone Marrow Stromal Antigen 2IBA 02/2011
1	Primaquine FDA Link 01/2011
1	Actins (F Actin)IBA 10/2008
1	GuanosineIBA 06/2008
1	ActomyosinIBA 06/2008
1	src-Family KinasesIBA 11/2007
1	Phosphotransferases (Kinase)IBA 11/2007
1	ChemokinesIBA 11/2006
1	Chemokine ReceptorsIBA 08/2006
1	Protein Sorting Signals (Signal Peptide)IBA 02/2006
1	Virulence Factors (Pathogenicity Factors)IBA 04/2005
1	Dynamins (Dynamin)IBA 02/2005
1	ClathrinIBA 02/2005
1	Human Immunodeficiency Virus Type 1 p24 proteinIBA 01/2005

Therapy/Procedure

3	Therapeutics 01/2022 - 03/2006